Overview

Stanford Accelerated Recovery Trial (START)

Status:
Terminated
Trial end date:
2016-07-01
Target enrollment:
0
Participant gender:
All
Summary
The goal of this study is to determine whether administering Gabapentin prior to surgery affects duration of pain and opioid use post-surgery. The investigators aim to compare gabapentin to placebo in a prospective, randomized clinical trial in which patients will be followed post-surgery until pain resolves and opioid use ceases.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Stanford University
Treatments:
Gabapentin
Lorazepam
Criteria
INCLUSION CRITERIA

- Age 18 to 75

- Undergoing a scheduled surgery

- English speaking

- Ability and willingness to complete questionnaires or use Palm Pilot

EXCLUSION CRITERIA

- Known kidney disease

- Currently receiving gabapentin or (pregabalin) lyrica already

- Cognitive impairment

- Previous history of excessive sedation or adverse reaction to gabapentin (not it was
tried but ineffective for nerve pain)

- Coexisting chronic pain > 4/10 disorder in area other than surgical target

- Plan to move out of state

- Condition that would in judgment of team member make patient likely to be lost to
follow-up

- Elevated suicidality

- Known pregnancy

- Current symptoms of ataxia, dizziness, or sedation

- Narrow angle glaucoma

- Severe respiratory insufficiency (ie, severe emphysema or chronic obstructive
pulmonary disease)

- History of gastric bypass surgery and obstructive sleep apnea requiring continuous
positive airway pressure (CPAP)