Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

• Status: Not yet recruiting
• Trial end date: 2026-01-08
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical trial is to test titrated oxygen in prehospital patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The main question it aims to answer is:

• To determine whether prehospital titrated oxygen strategy in patients with suspected AECOPD will decrease 30-day mortality compared to patients receiving standard care.

Participants in the intervention will receive titrated oxygen - a mix of supplemental oxygen and compressed atmospheric air as driver for inhaled bronchodilators to target SpO2 88-92%. The intervention will be compared to standard treatment, using compressed oxygen (100%) as driver for inhaled bronchodilators.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Central Denmark Region

Criteria

Inclusion Criteria:

• Patients over the age of 40

• EMT or Paramedic suspected AECOPD

• Confirmed suspicion of COPD

Exclusion Criteria:

• Bronchospasm due to asthma, allergic reaction or non-COPD conditions

• Known or suspected pregnancy

• Prehospital Non-invasive, invasive or assisted bag mask ventilation

• Allergy to inhaled bronchodilators (Salbutamol)

• Inter-hospital transfer

• More than 2 doses (5 mg salbutamol) inhalation drug, acute treatment by EMS personnel, before allocated treatment is initiated

• Suspicion of acute coronary syndrome