Standard Versus Transepithelial Corneal Crosslinking
Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
The gold standard corneal crosslinking (CXL) technique involves the initial step of
epithelial removal, in order to achieve a sufficient treatment effect (meaning: stabilisation
of progressive keratoconus (KC). Our aim is to evaluate the effects of transepithelial CXL
(TE-CXL), whereby the epithelium is left intact and the cornea is instead treated by a
solution composed of 0.1% riboflavin, combined with enhancers, after which standard CXL is
performed. This solution seems to facilitate riboflavin penetration into the corneal stroma
through the intact epithelium. The investigators expect to achieve a similar effect of TE-CXL
with the advantage of a faster healing time and less risk of infections.
Phase:
N/A
Details
Lead Sponsor:
Nienke Soeters
Collaborators:
Dr. F.P. Fischer Stichting Stichting Nederlands Oogheelkundig Onderzoek