St. John's Wort And Kava In The Treatment Of Major Depressive Disorder With Comorbid Anxiety
Status:
Completed
Trial end date:
2007-10-01
Target enrollment:
Participant gender:
Summary
SJW has the greatest evidence of herbal medicine efficacy in treating MDD. In treating
anxiety, kava has the greatest evidence of efficacy. As comorbidity of MDD and anxiety
commonly occurs, it is conceivable that a combination of an established antidepressant agent
such as SJW and an established anxiolytic agent such as kava may effectively treat MDD
presenting with comorbid anxiety. It is possible that a beneficial synergistic effect may
also occur between SJW and kava, improving the treatment outcomes in MDD with comorbid
anxiety, than by the individual substances alone. Determination of this is not addressed in
this study due to limitations of time and resources. The determination of the strength of the
SJW-kava combination will be ascertained by comparing similar trials using SJW and kava
mono-therapy in addressing MDD and GAD.
The hypothesis is that a combination of SJW and kava will reduce MDD occurring with comorbid
anxiety more than placebo.