Spreading Depolarization and Ketamine Suppression

• Status: Completed
• Trial end date: 2017-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Hypothesis: Cortical spreading depolarizations are inhibited by the NMDA receptor antagonist Ketamine Aim 1: To demonstrate, in a group of patients with acute severe brain injury requiring surgery including traumatic brain injury and aneurysmal subarachnoid hemorrhage, whether use of continuous infusion of ketamine decreases frequency of occurrence of cortical spreading depolarizations.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of New Mexico
• Treatments: Hypnotics and Sedatives; Ketamine

Criteria

Inclusion Criteria:

• GCS <8

• SAH or severe traumatic brain injury requiring craniotomy

• Consent obtainable (via legal representative)

• Ictus (bleed or injury) within 48 hours of enrollment

• Clinically appropriate for multimodality monitoring

Exclusion Criteria:

• Anticipated survival <48 hours

• No craniotomy

• Infratentorial craniotomy only•Unable to obtain consent

• Absence of clinically used multimodality monitoring

• Prisoners

• Pregnant