Spread of Muscle Hyperalgesia and Pain in a Low Dose NGF-induced Pain Model
Status:
Completed
Trial end date:
2017-10-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate and determine the time course and distribution on
muscle hyperalgesia and muscle pain in a repeated, low dose NGF model. It is hypothesized
that low dosages i.m injections of NGF are able to induce mechanical hyperalgesia and muscle
soreness in a same manner (effect of duration) as for dosages previously used in NGF studies.
Furthermore, it is also speculated if several injections of low dose NGF into the muscle
combined are able to course immediate pain sensation and spreading of muscle
hypersensitivity.