Split Face Study of the Duration of Local Anesthetics

• Status: Not yet recruiting
• Trial end date: 2024-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. This study will compare a short-acting anesthetic, lidocaine with epinephrine, to one of two long-acting anesthetics (ropivacaine or bupivacaine). This study will also directly compare the duration of actions of ropivacaine and bupivacaine. The investigators hypothesize that the duration of anesthesia of short-acting anesthetics will not differ significantly from long-acting anesthetics at a single site and there will not be a significant difference between the two long-acting anesthetics at a single site.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Weill Medical College of Cornell University
• Treatments: Bupivacaine; Epinephrine; Epinephryl borate; Lidocaine; Pharmaceutical Solutions; Racepinephrine; Ropivacaine

Criteria

Inclusion Criteria:

• Male or female ≥ 18 years of age

• Normal skin sensation at both nasal ala assessed by pinprick

• Ability to provide informed consent

Exclusion Criteria:

• Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated

• Pregnant or breastfeeding volunteers (assessed by self-report)

• Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types