Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery

• Status: Completed
• Trial end date: 2018-03-15
• Target enrollment: 0
• Participant gender: Female

Summary

Intrathecal (IT) opioids are commonly administered with local anesthetic during spinal anesthesia for post-Cesarean delivery analgesia. Traditionally, IT morphine has been used but the use of IT hydromorphone is growing. A previous study has shown that the effective dose for postoperative analgesia in 90% patients (ED90) for both IT hydromorphone and IT morphine (NCT02009722). These doses were found to be 75 mcg for hydromorphone and 150 mcg for morphine. The current proposed study would compare the duration of analgesia of IT morphine vs IT hydromorphone after elective cesarean delivery. Additionally, the investigators will compare each drug with respect the incidence of nausea and pruritus.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Anesthetics; Hydromorphone; Morphine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status II-III women presenting for elective cesarean delivery

• Term gestation (37-42 weeks)

• Desire to have a spinal anesthesia technique for cesarean delivery

Exclusion Criteria:

• Any contraindication to the administration of a spinal technique for anesthesia

• History of intolerance or adverse reaction to opioid medications

• Chronic pain syndrome or current opioid use >30 oral morphine equivalents/day

• Allergy or intolerance to acetaminophen, ketorolac, ibuprofen, or oxycodone

• Current BMI > 50