Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery
Status:
Completed
Trial end date:
2018-03-15
Target enrollment:
Participant gender:
Summary
Intrathecal (IT) opioids are commonly administered with local anesthetic during spinal
anesthesia for post-Cesarean delivery analgesia. Traditionally, IT morphine has been used but
the use of IT hydromorphone is growing. A previous study has shown that the effective dose
for postoperative analgesia in 90% patients (ED90) for both IT hydromorphone and IT morphine
(NCT02009722). These doses were found to be 75 mcg for hydromorphone and 150 mcg for
morphine. The current proposed study would compare the duration of analgesia of IT morphine
vs IT hydromorphone after elective cesarean delivery. Additionally, the investigators will
compare each drug with respect the incidence of nausea and pruritus.