Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines
Status:
Unknown status
Trial end date:
2021-07-01
Target enrollment:
Participant gender:
Summary
This study will compare a local anesthetic technique that has been used to treat subjects
suffering from transformed migraines (chronic migraines) versus medical management with
traditional antidepressant Amitriptyline / Elavil.
Subjects will be randomized into one of two treatment groups to compare the safety and
efficacy of the therapies. Subjects will recieve either sphenopalatine ganglion nerve block
with 5% lidocaine gel into the nasopharynx or medical management with traditional
antidepressants, Elavil, to produce a reduction in the frequency and severity of the
headache.
We propose that there will be a difference in the outcomes when comparing the two methods of
treating transformed migraines and that one research arm will result in more patient
satisfaction and greater efficacy in the treatment of subjects
Phase:
Phase 4
Details
Lead Sponsor:
Rutgers, The State University of New Jersey
Treatments:
Amitriptyline Amitriptyline, perphenazine drug combination Lidocaine