The purpose of this research study is to assess the feasibility of using spesolimab in
participants with moderate to severe pyoderma gangrenosum. Pyoderma gangrenosum is a rare,
inflammatory, autoimmune condition which results in ulceration of skin. The study will also
investigate the body's immune response to the spesolimab (when the body detects and defends
itself against substances that appear unknown and harmful).