Specific PET Radioligand Binding to Translocator Protein
Status:
Completed
Trial end date:
2016-11-23
Target enrollment:
Participant gender:
Summary
Background:
- A brain protein called translocator protein (TSPO) shows changes in some brain diseases. A
radioactive drug called 11C-(R)-PK 11195 is used to take pictures of TSPO using a camera
called positron emission tomography (PET). Researchers want to find out how well 11C-(R)-PK
11195 takes the pictures.
Objective:
- To evaluate the radioactive chemical 11C-(R)-PK 11195.
Eligibility:
- Healthy volunteers ages 18-55.
Design:
- Participants will be screened with a medical exam.
- Participants will have scans at up to 4 visits.
- PET scan using 11C-(R)-PK 11195:
- A small tube (catheter) will be put into an artery at the wrist or elbow, by a
needle. The needle will be removed, leaving only the catheter in the artery.
Blood samples will be taken through this catheter.
- Another catheter will be placed into a vein in the arm or hand.
- 11C-(R)-PK 11195 will be injected through the second catheter.
- The PET scanner is shaped like a doughnut. Participants will lie on a bed that
slides in and out of it. They may get a plastic mask for their face and head.
- Participants will receive a dose of emapunil by mouth. Participants will then have
another PET scan.
- Participants may have a magnetic resonance imaging (MRI) scan. The MRI scanner is a
metal cylinder surrounded by a magnetic field. The participant will lie on a table
that can slide in and out of the cylinder. Participants will get earplugs for the
loud knocking noises.
- After each scan, participants will get a follow-up phone call. Two to seven days after
taking emapunil, participants will return for a follow-up visit.