Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors
Status:
Completed
Trial end date:
2010-11-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Sorafenib and pemetrexed may stop the growth of tumor cells by blocking some of
the enzymes needed for cell growth. Sorafenib may also stop the growth of tumor cells by
blocking blood flow to the tumor. Drugs used in chemotherapy, such as cisplatin, work in
different ways to stop the growth of tumor cells, either by killing the cells or by stopping
them from dividing. Giving sorafenib together with pemetrexed and cisplatin may kill more
tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of sorafenib when
given together with pemetrexed and cisplatin in treating patients with advanced solid tumors.