Somatostatin Analogue SOM230 (Pasireotide) in Healthy Male Volunteers
Status:
Completed
Trial end date:
2010-04-01
Target enrollment:
Participant gender:
Summary
This clinical study will attempt to find out why in early studies in healthy volunteers,
injections under the skin of pasireotide were associated with temporary increases in both
fasting and post-meal glucose levels, along with possible increases in insulin and glucagon
levels. Glucose refers to the amount of sugar in your blood and insulin and glucagon levels
are amounts of hormones that lower and raise blood sugar.
The purpose of the study is to evaluate the effects of pasireotide on insulin resistance and
secretion. Insulin is a natural hormone made by the pancreas (a gland inside the abdomen)
that controls the level of sugar in the blood. Insulin permits cells to use sugar for energy.
Insulin resistance is the condition in which higher than normal amounts of insulin are
necessary to allow the sugar to enter the cells. Insulin secretion refers to the amount of
insulin produced by the body and released in the blood. Glucagon is a hormone (chemical
substance produced by the pancreas gland in the body) which increases blood glucose.