Soluble Corn Fiber Supplementation for Asthma

• Status: Unknown status
• Trial end date: 2020-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Studies of the importance of the human microbiome have demonstrated that microbial metabolites of fermentation of our dietary products (e.g. dietary fiber) have a multitude of health benefits. The investigators aim to determine whether supplementation of asthmatic children with soluble corn fiber alongside standard of care reduces airway inflammation driven by the gut microbial metabolites acetate, propionate, or butyrate (short chain fatty acids).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Phoenix Children's Hospital
• Collaborators: Flinn Foundation; Mayo Clinic; Northern Arizona University

Criteria

Inclusion Criteria:

• Clinical diagnosis of asthma

• Fractional excretion of exhaled nitric oxide (FeNO) > 50 ppb OR a history of environmental allergies

• No emergency department or hospital visits for asthma in the past 3 months

• No systemic corticosteroids in the past 1 month

• Ability to consume a liquid drink of SCF or placebo

• Ability to return for a 4-6 week follow-up visit

• No special or unique diet as determined by PI/CO-Is.

Exclusion Criteria:

• Cystic fibrosis

• Bronchiectasis

• Change in asthma medicines other than short acting bronchodilators planned over the next 4-6 weeks.