Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Sodium stibogluconate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Interferon alfa-2b may interfere with the growth of tumor cells and slow the growth of melanoma and other cancers. Drugs used in chemotherapy, such as cisplatin, vinblastine, and dacarbazine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sodium stibogluconate and interferon alfa-2b together with combination chemotherapy may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of sodium stibogluconate when given together with interferon alfa-2b, cisplatin, vinblastine, and dacarbazine in treating patients with advanced melanoma or other cancer.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Case Comprehensive Cancer Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Antimony Sodium Gluconate; Cisplatin; Dacarbazine; Interferon alpha-2; Interferon-alpha; Interferons; Vinblastine

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed melanoma or other malignancies

• Must be refractory or resistant to established treatments OR have metastatic disease for which no effective therapy has been established

• Gliomas or controlled CNS metastasis allowed

• A CT scan or MRI must confirm stable brain metastases within 28 days of study entry

• Patients with primary CNS malignancies refractory to other therapies are eligible

• Malignancy potentially responsive to sodium stibogluconate and/or interferon alfa-2b and combination chemotherapy

• Patients must have measurable or evaluable disease

• Evaluable disease can include clinically or radiographically nonmeasurable tumor, specific tumor markers, or stage IV patients with no evidence of disease (NED)

PATIENT CHARACTERISTICS:

• Inclusion criteria:

• ECOG performance status 0-2

• Granulocytes > 1,500/μl

• Platelets > 100,000/μl

• Creatinine < 1.5 x upper limit of normal (ULN)

• Bilirubin < 1.5 x ULN

• AST and ALT < 1.5 x ULN (unless due to hepatic metastases)

• Potassium ≤ 5.0 mmol/L

• Magnesium ≤ 2.4 mg/dL

• Creatinine clearance ≥ 60 cc/min

• Ejection fraction ≥ 50%

• Exclusion criteria:

• Pregnant or lactating women and fertile women or men unless surgically sterile or using effective contraception

• All female patients of childbearing potential or less than 1 year postmenopausal must have a negative β-HCG pregnancy test at baseline and practice a medically acceptable method of birth control (i.e., oral contraceptives for at least 3 months, implantation of an intrauterine device for at least 2 months, or barrier methods [e.g., vaginal diaphragm, vaginal sponge, or condom with spermicidal jelly]) during and for 3 months after study initiation

• History of atrial fibrillation, flutter, or other serious arrhythmia (excluding asymptomatic atrial or ventricular premature complexes) in the past 24 months

• History of congestive heart failure currently requiring treatment; angina pectoris; or other severe cardiovascular disease (i.e., New York Heart Association class III or IV heart disease)

• Baseline ECG abnormalities suggestive of cardiac conduction delay (i.e., first degree or greater atrio-ventricular block and/or complete or incomplete [QRS > 120 ms] bundle branch block)

• Baseline ECG abnormalities suggestive of repolarization abnormalities (i.e., QTc ≥ 0.48 sec)

• Culture positive acute infections requiring antibiotics within the past 14 days

• Patients on long term suppressive antibiotic therapies are eligible

• Known to be positive for HBsAg

• Patients judged to not be psychologically prepared to understand informed consent or comply with an investigational study

PRIOR CONCURRENT THERAPY:

• Inclusion criteria:

• Prior interferon therapy is allowed if administered ≥ 4 months ago

• At least 3 weeks since prior major surgery, radiation therapy, or chemotherapy

• Exclusion criteria:

• No prior treatment with interferon, sodium stibogluconate, cisplatin, vinblastine, or dacarbazine, except if given in an adjuvant setting

• Patients with a prior history of solid organ allografts or allogeneic bone marrow transplant

• Patients taking the following medications will not be eligible:

• Amiodarone (Cordarone)

• Disopyramide (Norpace)

• Dofetilide (Tikosyn)

• Procainamide (Procanbid or Pronestyl)

• Quinidine (Quinaglute)

• Sotalol (Betapace)

• Erythromycin

• Azithromycin (Z-pack)

• Clarithromycin (Biaxin)

• Pentamidine (Pentacarinat)

• Trimethoprim-sulfamethoxazole (Bactrim)

• Bepridil (Vascor)

• Phenothiazines (e.g., prochlorperazine [Compazine], promethazine [Phenergan], or chlorpromazine [Thorazine])

• Butyrophenones (e.g., Haloperidol [Haldol])

• Risperidone (Risperdal)

• Any other antipsychotic medication

• Tricyclic or tetracyclic antidepressants (e.g., imipramine [Tofranil], amitriptyline [Elavil], desipramine [Norpramin], or nortriptyline [Pamelor])

• Monoamine oxidase inhibitors

• High-dose methadone

• Arsenic trioxide

• Dolasetron (Anzemet)

• Any herbal preparations

• Use of daily glucocorticoids except for physiological replacement