Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

This study evaluates the intervention of the 1) sodium-restricted diet, or 2) diuretic, or 3) placebo pill in the treatment of obstructive sleep apnea in adults.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospital de Clinicas de Porto Alegre
• Treatments: Diuretics; Furosemide; Spironolactone

Criteria

Inclusion Criteria:

• Men in the age range from 18 to 60 years

• Full-night in-laboratory polysomnography with apnea-hypopnea index > 30/h in the last three months

• Body mass index < 35 kg/m2

• Informed consent

Exclusion Criteria:

• Already having started any treatment for sleep apnea, including use of continuous positive airway pressure

• NYHA heart failure, any class

• Predominantly central apnea

• Peripheral venous or lymphatic insufficiency

• Any chronic renal disease

• Use of diuretics and substances with action in the central or peripheral nervous system such as benzodiazepines, hypnotics, anticonvulsants, antidepressants, appetite suppressants, amphetamines, antiparkinson agents, muscle relaxants, bronchodilators

• Stroke within 6 months or with incapacitating sequelae

• Any physical, mental or social condition impairing the ability to participate in the trial