The proposed research will determine the effectiveness of nitrite, a naturally occurring
compound in the body, for improving the health and function of arteries in middle-aged and
older adults. The study also will provide insight into how sodium nitrite therapy improves
artery health by determining the physiological mechanisms (biological reasons) involved.
Overall, the proposed research will provide important new scientific evidence on the
effectiveness of sodium nitrite for decreasing the risk of developing cardiovascular diseases
with aging.