Resection surgery of brain tumors by craniotomy requires efficient brain relaxation
intraoperatively in order to avoid injuries caused by the brain retractors (such as
ischemic-reperfusion and cerebral oedema). The gold standard for the brain relaxation during
a surgery is Mannitol 20%.
Molar sodium lactate is now used to induce brain relaxation in patients with traumatic brain
injury and intracranial hypertension due to its osmotic effect. Furthermore, the injection of
sodium lactate may lead to better neuronal metabolism during cerebral aggression, and may
participate to the reduction of cerebral oedema and secondary injuries.
LSD is a pilot randomised trial which tries to assess the interest of intravenous
administration of molar Sodium Lactate on the quality of brain relaxation in surgical
resection of supratentorial brain tumors by craniotomy.
The primary outcome measure is the quality of brain relaxation, evaluated by neurosurgeon at
the opening of the dura, by a validated brain relaxation scale.