Sodium Chloride and Protein-Bound Toxin Removal in Hemodiafiltration

• Status: Unknown status
• Trial end date: 0000-00-00
• Target enrollment: 8
• Participant gender: Both

Summary

An increase of the free fraction may allow a better removal of of protein-bound uremic toxins during dialysis. During predilution hemodiafiltration, the sodium chloride (NaCl) concentration will be increased in the infusion fluid at a target NaCl concentration and the effect on the removal of protein-bound toxins will be determined. Comparisons will be made to standard hemodialysis and hemodiafiltration.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: EXcorLab GmbH
• Last Updated: 2013-08-14

Criteria

Inclusion Criteria:

• End-stage renal disease

• Maintenance hemodialysis or hemodiafiltration for more than 3 months

• Stable clinical condition

• > 18 years

Exclusion Criteria:

• Life expectancy less than 1 year

• Pregnancy

• Active infectious disease