Overview
Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy
Status:
Completed
Completed
Trial end date:
2006-03-01
2006-03-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans. We compared the efficacy of sodium bicarbonate versus isotonic saline to prevent CIN in a large population of patients with renal dysfunction undergoing coronary angiography or intervention.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Ospedale Misericordia e Dolce
Criteria
Inclusion Criteria:- patients with creatinine clearance < 60 mL/min
Exclusion Criteria:
- contrast medium administration within the previous 10 days
- end-stage renal failure requiring dialysis
- refusal to give informed consent