Overview Smoking by IV Pulsed Nicotine Status: Completed Trial end date: 2021-05-31 Target enrollment: Participant gender: Summary To establish a dose-effect curve for nicotine's abuse potential as a function of nicotine dose and delivery rate. Pulsed IV nicotine administration will be used as it closely matches nicotine delivery by inhaled tobacco use. Phase: Early Phase 1 Details Lead Sponsor: Yale UniversityTreatments: Nicotine