Objectives:
Primary Aim:
To conduct a preliminary randomized trial in smokers with current recurrent major depressive
disorder (MDD), current MDD with a single episode of 2 years or more, and current dysthymia
comparing combined cognitive behavioral analysis system of psychotherapy (CBASP) and standard
smoking cessation treatment (ST) (CBASP/ST) to combined Health Education and ST treatment
(HE/ST) to:
1. Examine the effects of CBASP/ST on both short and long-term point prevalence abstinence
Secondary Aims:
1. To test the hypothesis that depressed smokers in the CBASP/ST treatment will experience
greater decreases in depressive symptoms from baseline to each of our follow-up
assessment points, compared to depressed smokers in the HE/ST treatment, and;
2. That depressed smokers in the CBASP/ST treatment will experience greater improvements in
psychosocial functioning from baseline to follow-up assessment points, compared to
depressed smokers in the ST treatment.
3. To evaluate between subject neurophysiological predictors of abstinence at 3 and 6
months, and:
4. To evaluate within-subject changes in neurophysiological responses to emotional and
smoking-related stimuli across treatment sessions, and the relation of these changes to
abstinence and depressive symptoms at end of treatment, and 3- and 6-months.