Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) - Phase I
Status:
Recruiting
Trial end date:
2023-08-01
Target enrollment:
Participant gender:
Summary
Our overall hypothesis is that sleep slow-wave potentiation by propofol is a therapeutic
pathway for alleviating treatment-resistant depression (TRD).
This investigation aims to establish:
Aim 1: Establish the safety and feasibility of multiple propofol infusions targeting of
electroencephalographic (EEG) slow-wave activity (SWA) without burst suppression in geriatric
patients with treatment-resistant depression (TRD) patients.
Prospective, mechanistic, open-label for safety/feasibility pilot study (target enrollment =
15)