Goal of this project is to investigate whether increases in inflammation that result from
common patterns of restricting sleep on week nights and catching up on sleep over the weekend
are caused by disruption in the newly discovered inflammatory resolution pathways. These
pathways are crucial in the active termination of the inflammatory response, and their
disruption may contribute to ongoing unresolved inflammation, which has been observed not
only during periods of sleep restriction, but also after recovery sleep has been obtained. If
the hypothesis is true, it is possible that increasing the body's natural production of
endogenous, inflammatory resolution mediators may provide a non-behavioral strategy to limit
the inflammatory consequences in those undergoing periods of sleep restriction with
intermittent recovery sleep.