Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals

• Status: Completed
• Trial end date: 2003-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine the effectiveness of total sleep deprivation (TSD) for one night plus paroxetine versus either TSD plus placebo or paroxetine alone in inducing rapid symptom resolution of major depression in the elderly.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pittsburgh
• Treatments: Paroxetine

Criteria

Inclusion Criteria:

• Age 60 and older

• Current episode of unipolar, major depression

• HRSD (17 item)score of 15 or higher

• Folstein Mini-Mental Status exam score of 17 or higher

Exclusion Criteria:

• Lifetime diagnosis of any psychotic disorder

• Lifetime diagnosis of bipolar disorder

_Alcohol or drug abuse within the past 6 months

• Contraindication to treatment with SSRI therapy

• History of seizure disorder

• Baseline apnea/hypopnea index of 20 or higher

• Hyponatremia