Sleep Apnea: Mechanism and Cerebrovascular Consequences
Status:
Withdrawn
Trial end date:
2007-05-01
Target enrollment:
Participant gender:
Summary
This study will determine the effect of ventilatory stimulation on obstructive sleep apnea in
selected patients with stroke. We will select a subset of patients with stroke in the prior 3
months who are most likely to have ventilatory instability as a cause of the upper airway
obstruction as indicated by the absence of obesity, an abnormal hypocapnic apnea threshold
and resolution of obstructive apnea during CO2 administration. Following baseline
polysomnography, patients will be randomly assigned to acetazolamide (250 mg hs [at bedtime])
versus placebo for 7 days. Polysomnography will be repeated and then subjects will cross-over
therapies for another 7 days followed by a final nocturnal polysomnography.
Phase:
N/A
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development