Sitravatinib and Tislelizumab in Patients With Metastatic Uveal Melanoma With Liver Metastases.
Status:
Not yet recruiting
Trial end date:
2024-08-01
Target enrollment:
Participant gender:
Summary
SITISVEAL stablish the hypothesis that treatment with Tislelizumab + Sitravatinib will
increase the Objective Response Rate in patients with Metastatic Uveal Melanoma (mUM) with
liver metastases, compared with the current standard of care.
This is a non-randomized, single arm, multicenter, phase II study of Sitravatinib in
combination with Tislelizumab in subjects with metastatic uveal melanoma and liver
metastases. After informed consent is obtained, subjects will enter in the Screening phase to
assess eligibility criteria and perform a mandatory tumor biopsy. Upon meeting criteria,
eligible subjects will be entered into the Treatment phase. Patients will receive
Sitravatinib 100 mg orally once daily in combination with tislelizumab 200 mg IV once every 3
weeks until progression of disease, unacceptable toxicity, death, or consent withdrawal,
whichever occurs first. Treatment may be continued after progression according to physician
criteria (with previous consultation with Coordinating investigator) until patients no longer
receive clinical benefit.