Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease
Status:
Recruiting
Trial end date:
2022-06-30
Target enrollment:
Participant gender:
Summary
Higher consumption of fruits and vegetables promote greater availability of phenolic
compounds and these compounds were associated with vascular health. Quercetin, a phenolic
compound, is the most abundant natural antioxidant belonging to the group of flavonoids.
Quercetin improved lipoprotein metabolism, had antioxidant capacity, produced vasodilating
substances in the vascular endothelium and reduced platelet aggregability. Likewise, statins
are medications known to reduce cardiovascular events in women with coronary disease by
reducing serum LDL-cholesterol. Therefore, a number of metabolic pathways are responsible for
vascular health. The serum concentration and gene expression of sirtuin 1 (Sirt1) and RAGE
soluble (sRAGE) are directly associated with vascular protection. This study will analyse the
influence of atorvastatin and quercetin on serum concentrations and gene expression of Sirt1
and sRAGE in postmenopausal women with stable coronary artery disease.