Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects.
Status:
Not yet recruiting
Trial end date:
2027-02-01
Target enrollment:
Participant gender:
Summary
All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for
cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin
sensitivity, glucose tolerance, and β-cell function). Older obese participants will be
randomized into three arms: lifestyle intervention (n=24), senolytics (n=24), or placebo
(n=24).
Phase:
Early Phase 1
Details
Lead Sponsor:
The University of Texas Health Science Center at San Antonio