Single Low Dose Tafenoquine to Reduce P. Falciparum Transmission in Mali (NECTAR2)
Status:
Completed
Trial end date:
2020-12-23
Target enrollment:
Participant gender:
Summary
The purpose of this study is to assess the gametocytocidal and transmission reducing activity
of dihydroartemisinin-piperaquine (DP) with and without various low doses of tafenoquine (TQ;
1.66mg/kg, 0.83mg/kg, or 0.415mg/kg). Outcome measures will include infectivity to mosquitoes
at 2 and 7 days after treatment, gametocyte density throughout follow-up, and safety measures
including haemoglobin density.