Single Dose of Clonazepam Versus Intermiittent Diazepam for Febrile Seizures Prevention

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To study the efficacy and safety of single dose clonazepam compared with intermittent oral diazepam for prevention of recurrent febrile seizures in children who had three or more febrile seizures.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Queen Sirikit National Institute of Child Health
• Treatments: Clonazepam; Diazepam

Criteria

Inclusion Criteria:

• age 6-60 months at date of enrollment

• 3 or more episodes of clinically diagnosed febrile seizures

Exclusion Criteria:

• history of afebrile seizures or any history suggested the epilepsy

• history of previous brain insults; CNS infection, birth trauma, traumatic brain injury.

• delayed developmental milestones

• abnormal neurological examinations

• currently treatment by continous antiepileptic drug(s)

• A contraindication to Clonazepam, Diazepam such as drug hypersensitivity, liver disease.

• Predictable lack of available of follow up.