Overview

Single Ascending Doses of ZP4207 Administered in HV and in T1D to Evaluate Safety, Tolerability PKs and PDs of ZP4207 Compared to a Comparator

Status:
Completed
Trial end date:
2015-04-01
Target enrollment:
0
Participant gender:
Male
Summary
The trial is a randomized, double-blind First in Human trial to evaluate the safety and tolerability of ZP4207 in healthy volunteers (HV) and in insulin-induced hypoglycemic T1D (type 1 diabetes) subjects as compared to native glucagon. The trial includes two parts. Part 1 includes dose escalation of ZP4207 in cohorts of 8 subjects. In each cohort, subjects will be randomized 3:1 to receive either a single ascending dose of ZP4207 (6 subjects) or a single fixed dose (SD) of native glucagon (2 subjects). The doses will be administered s.c. in 4-5 cohorts and i.m. in 3 cohorts. Part 2 includes two sequence groups of 10 hypoglycemic T1D subjects. The subjects will be treated with fixed single doses of ZP4207 and native glucagon s.c. in a sequential cross-over design in a randomized treatment order.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Zealand Pharma
Treatments:
Glucagon
Glucagon-Like Peptide 1
Criteria
Inclusion Criteria:

1. Informed consent obtained before any trial-related activities. (Trial-related
activities are any procedure that would not have been performed during normal
management of the subject).

2. Male subjects which are healthy for part 1; for part 2 male subjects with T1D

3. Age between 18 and 50 years, both inclusive.

4. Body weight between 70 and 90 kg, both inclusive.

5. Subjects must be in good health according to age (medical history, physical
examination, vital signs, ECG, lab assessments), as judged by the investigator

6. A subject who is surgically sterilized or must be willing to refrain from sexual
intercourse during the trial and until one month after completion of the trial or if
sexually active, using condom and partner practices contraception during the trial and
until one month after completion of the trial.

For part 2, in addition:

7. Male subjects with T1D for at least one year, as defined by the American Diabetes
Association.

8. Having been treated with insulin for T1D for at least 1 year.

9. Stable disease with HbA1c < 8.5 %.

10. Stable insulin treatment during participation in trial and 3 month prior to the
screening visit.

Exclusion Criteria:

1. Known or suspected allergy to trial product(s) or related products.

2. Previous participation (randomization) in this trial.

3. Receipt of any investigational drug within 3 months prior to screening.

4. A history or presence of cancer, diabetes (part 1 only), or any clinically significant
cardiovascular, respiratory, metabolic, renal, hepatic, gastrointestinal,
endocrinological, hematological, dermatological, venereal, neurological, psychiatric
diseases or other major diseases.

5. Clinically significant illness within 4 weeks before screening, as judged by the
investigator

6. Carrier of Hepatitis B surface antigen (HBsAg) or Hepatitis C antibodies.

7. Positive result of test for HIV antibodies.

8. Any clinically significant abnormal hematology,biochemistry or urinalysis screening
tests, as judged by the Investigator.

9. Clinically significant abnormal ECG at screening as evaluated by Investigator.

10. Donation of blood or plasma in the past month, or in excess of 500 ml within 12 weeks
prior to screening.

11. A significant history of alcoholism or drug/chemical abuse, or who has a positive
result in the urine drug screen, or who consumes more than 28 units of alcohol per
week (one unit of alcohol equals about 250 ml of beer, 1 glass of wine, or 20 ml of
spirits).

12. Habitual smoking, i.e., daily smoking or more than 7 cigarettes/week within the last 3
months prior to screening. Subjects have to accept refraining from smoking while at
the clinical site.

13. Subjects with mental incapacity or language barriers which preclude adequate
understanding or cooperation, who are unwilling to participate in the trial, or who in
the opinion of the Investigator should not participate in the trial.

14. Surgery or trauma with significant blood loss within the last 2 months prior to
screening.

15. Any condition interfering with trial participation or evaluation or that may be
hazardous to the subject.

For part 2, in addition

16. Severe hypoglycemic events within one year prior to screening, as judged by the
investigator.

17. Significant changes in basal insulin within 3 weeks before screening, as judged by the
investigator.

18. Clinically relevant diabetic complications (macrovascular disease with symptoms of
coronary artery disease or peripheral vascular disease, microvascular disease with
symptoms of neuropathy, gastroparesis, retinopathy, nephropathy, or poor blood glucose
control with polyuria, polydipsia, or weight loss), as judged by the investigator.