Overview

Single Arm Trial of Tumor-Treating Fields in Combination With Nivolumab and Ipilimumab in Metastatic Uveal Melanoma

Status:
Not yet recruiting
Trial end date:
2025-08-29
Target enrollment:
0
Participant gender:
All
Summary
Tumor Treating Fields targeted to liver metastases may improve outcomes for patients with metastatic uveal melanoma treated with immune checkpoint inhibitors.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
HonorHealth Research Institute
Collaborator:
NovoCure Ltd.
Treatments:
Ipilimumab
Nivolumab
Criteria
Inclusion Criteria:

1. Patient has histologically or cytologically confirmed metastatic uveal melanoma with
predominant liver involvement

2. Age 18 years or older and willing and able to provide informed consent

3. WOCBP must have a negative serum pregnancy test documented with 72 hours of first
administration of drug

4. Sexually active and WOCBP, patient and partner must agree to use adequate
contraception

5. Normal organ and marrow function

6. ECOG 0-1

7. Life expectancy of 3 months or greater

Exclusion Criteria:

1. History of previous grade 3, life threatening immune related adverse event (irAE) from
prior checkpoint inhibitor therapy

2. Prior treatment with anti cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) therapy
within 90 days of C1D1 of study treatment

3. Prior anti-cancer therapy (systemic, regional or radiation) within 2 weeks of C1D1 of
study treatment

4. AEs from prior anticancer therapies that have not resolved to grade 1 or less, other
than endocrine related irAEs for which patients are on appropriate replacement therapy
(ie hypothyroidism, adrenal insufficiency, type 1 diabetes)

5. History of or active autoimmune disease requiring systemic corticosteroid or
immunosuppressive therapy. (Patients who have limited autoimmune disease not requiring
systemic therapy or autoimmune disease that is unlikely to recur, such as ulcerative
colitis s/p colectomy, will be allowed to enroll.)

6. Serious medical risk factors involving any of the major organ systems such that the
Investigator considers it unsafe for the patient to receive an experimental research
drug.

7. Patient is unwilling or unable to comply with study procedures

8. Patients with implanted pacemaker, defibrillator, nerve stimulator or other active
electronic medical devices; sensitive to conductive hydrogels used on
electrocardiogram (ECG) stickers or transcutaneous electrical nerve stimulation (TENS)
electrodes typically used for TTFields studies.