Single Arm Study of Induction Chemoradiotherapy Combined With Surgery in the Treatment of Locally Advanced SNMM
Status:
Recruiting
Trial end date:
2025-08-10
Target enrollment:
Participant gender:
Summary
Sinonasal mucosal melanoma (SNMM) is a very rare tumor, and SNMM is highly aggressive in
nature, with a 5-year survival rate of about 20~30%. Most patients underwent local recurrence
and distant metastasis within one or two years of treatment.
There is no unified standard for the treatment of SNMM.The principle of treatment for
surgically resectable stage T3 and partial T4 SNMM is complete resection of the primary
tumor, combined with postoperative radiotherapy. While locally unresectable SNMM has a poorer
prognosis, lower incidence, fewer clinical data have been reported.
This study will explore the role of preoperative radiotherapy and chemotherapy in improving
the 2-year OS rate, loco-regional control rate and distant metastasis rate.