Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors
Status:
Completed
Trial end date:
2019-09-22
Target enrollment:
Participant gender:
Summary
This is a Phase I trial with new experimental drugs such as simvastatin in combination with
topotecan and cyclophosphamide in the hopes of finding a drug that may work against tumors
that have come back or that have not responded to standard therapy. This study will define
toxicity of high dose simvastatin in combination with topotecan and cyclophosphamide and
evaluate for cholesterol levels and IL6/STAT3 pathway changes as biomarkers of patient
response.