Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis
Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
Modified perforated membrane (MPM) is considered as a modality that could enable
participation of periosteal cells and gingival stem cells which could improve the outcomes of
guided tissue regeneration more than the use of the traditional occlusive membrane (OM).
Simvastatin (SMV) modulates bone formation by increasing the expression of bone morphogenetic
protein 2 and angiogenesis. Ethylenediaminetetraacitic acid (EDTA) found to be effective as
low ph etchant for smear layer removal and exposing root surface collagen. The investigators
compared the clinical and radiographic outcome of SMV gel combined with MPM to SMV gel
combined with OM with and without an associated EDTA gel root surface etching for improving
bone regeneration in intrabony defects in chronic periodontitis patients. Moreover,
evaluation of SMV gingival crevicular fluid (GCF) levels availability for 30 days in cases
with and without EDTA root surface etching was performed.