Simvastatin Effect on Portal Hypertension

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: All

Summary

It´s a clinical research of the effects in portal hypertension caused by simvastatin. We are going to use the hepatic venous pressure gradient(HVPG) measurement and the azygos flow at echoendoscopy to evaluate the benefits of the drug. Preliminary studies demonstrated that simvastatin can lower portal pressure.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universidade Federal do Rio de Janeiro
• Collaborator: Rio de Janeiro State Research Supporting Foundation (FAPERJ)
• Treatments: Simvastatin

Criteria

Inclusion Criteria:

• Portal hypertension: esophageal varices, ascites, splenomegaly or hepatorenal syndrome.

Exclusion Criteria:

• Child-Pugh C decompensated or encephalopathy

• Malignancy except basocellular cancer

• Hepatocarcinoma

• Anti-viral therapy

• HIV

• Prevention of digestive hemorrhage with band ligation or sclerotherapy for the last 6 months