The spontaneous passage rate for ureteral stone less than 1cm causing acute ureteral
obstruction is about 50%. Previous Cochrane review has concluded that alpha blocker is likely
to increase stone passage rate, reduce time to stone passage, analgesic use and
hospitalisations. The European Association of Urology Guideline also recommends giving alpha
blockers as Medical Expulsive Therapy to patients with distal ureteric stones >5mm. However
there is heterogeneity in different alpha blockers.
Silodosin is a recently introduced selective alpha blocker which has a much higher
selectivity for the alpha-1-A receptor (17-fold compared with tamsulosin). From previous
animal studies, ureteral contraction is mainly mediated by the alpha-1-A receptor, hence
silodosin maybe more effective in increasing stone passage compared with tamsulosin.
Previous studies and meta-analysis has shown superiority of silodosin over tamsulosin on
earlier stone passage and less pain. However, there is no data on Chinese population.
The investigators would like to compare the efficacy and side effect profile of Silodosin
versus tamsulosin on improving stone passage rate and hence reduce rate of further
intervention for stone clearance.