Milk thistle is an herbal drug that may have some liver protection properties and may reduce
inflammation in the liver. It may also have anticancer effects. However milk thistle is not
approved by the Food and Drug Administration for any medical purpose in the United States.
It has not been used in patients with liver cancer previously, to our knowledge, but there
have been many studies of its use in patients with hepatitis and cirrhosis. Some of these
studies have shown that milk thistle may help reduce elevated liver function tests.
Siliphos is a derivative of milk thistle that can be absorbed better than some other types of
milk thistle. The investigators would like to perform a study to identify doses of siliphos
that are safe to take in advanced liver cancer and to identify positive or negative side
effects this compound may have. The investigators will be using this information in future
studies to see if siliphos can be used as a therapy in patients with advanced liver cancer to
reduce elevated liver function tests.