Sildenafil for Chronic Obstructive Pulmonary Disease

• Status: Completed
• Trial end date: 2008-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if sildenafil improves the exercise capacity and lung function of patients with chronic obstructive pulmonary disease.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kawut, Steven, MD
• Collaborator: Pfizer
• Treatments: Citric Acid; Sildenafil Citrate

Criteria

Inclusion Criteria:

• Clinical diagnosis of chronic obstructive pulmonary disease (COPD) or emphysema

• FEV1/FVC ratio < 70%

• FEV1 < 80%

• Stable medication regimen

Exclusion Criteria:

• COPD exacerbation or hospitalization in the past 3 months

• Heart disease

• Contraindication to sildenafil

• Unrelated lung disease

• Inability to walk or pedal on a stationary bike

• Pregnancy or breast-feeding

• Pulmonary hypertension at rest