Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium
Status:
Completed
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
This is a prospective self controlled clinical trial. Women with clomiphene Citrate failure,
and thin endometrium were recruited (N = 42). In their 6th (Clomiphene citrate only) cycle,
women continued on Clomiphene citrate 100 mg/ day for 5 days, and had sonographic measurement
of their endometrial thickness , and Doppler evaluation of their uterine arteries on the day
of HCG administration. In 7th cycle, women (N = 36) were given usual dose of Clomiphene
citrate supplemented with sildenafil vagina gel (5 gm, containing 50 mg sildenafil) twice
daily from cycle day 8 till the day of HCG injection. Endometrial thickness and uterine
artery Doppler were measured on the day of HCG administration.