Shugan Dingtong Decoction in the Treatment of Fibromyalgia
Status:
Not yet recruiting
Trial end date:
2024-08-31
Target enrollment:
Participant gender:
Summary
Fibromyalgia (FM) is a syndrome characterized by chronic and widespread musculoskeletal pain,
fatigue sleep disturbances and cognitive and somatic symptoms. It is commonly conjectured
that central sensitization is physiological hallmark of FM. Therefore, centrally acting
medications including antidepressants and anticonvulsants are used to treat FM via
downregulating dorsal horn sensitization and systemic hyperexcitability.However, those drugs
are limited in clinical practice resulting from dose-limiting adverse effects and incomplete
drug efficacy.Shugan Dingtong decoction(SGDTD) is a Chinese herbal formula and has been used
for treatment of FM in clinical practice many years. However, few research can provide
high-quality evidence on the efficacy and safety of SGDTD for the treatment of FM. Therefore,
a parallel-group randomized controlled trial was designed to evaluate the efficacy and safety
of SGDTD on FM.