Short-term Effect of Extended-release Niacin on Endothelial Function.
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Individuals with reduced plasma concentration of high-density lipoprotein (HDL) cholesterol
are more susceptible to oxidative stress and often present reduced endothelial function,
which has been mainly related to this susceptibility. Studies in animal and cell models have
demonstrated that niacin activates both GPR-109A in leukocytes and heme oxygenase-1 (HO-1)
pathway promoting strong anti-inflammatory and anti-oxidative effects. . In this context, the
aim of this study was to investigate the short-term effect of niacin on endothelial function
and verify the existence of interaction of PGD2 receptor antagonist, i.e. laropiprant (LRPT),
in subjects with low HDL-cholesterol (HDL -C).