Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
Periodontal disease (PD) is an inflammatory, infectious and destructive condition of the
tissues surrounding the teeth. However, even if bacteria are required to initiate periodontal
disease, the immune response is responsible for most of the destruction of the periodontal
tissues. Statins may be used to control the immune response to periodontal pathogens, a
factor that has not yet been managed clinically and even less massively.
Recently it has been reported the pharmacological effectiveness of topically used statins.
For periodontal disease, at least four well conducted clinical trials have been published
using a topically statin formula for pocket irrigation in adult populations with chronic
periodontal disease, observing surprising clinical results in all of them (with clinical and
statistical significance) and no adverse reactions.
The purpose of the present study is asses the effectiveness of a medicated 2% atorvastatin
dentifrice, as complement to non-surgical conventional periodontal treatment. Clinical
examination will be made at the beginning and after one month of treatment.
Phase:
Phase 2
Details
Lead Sponsor:
Universidad de los Andes, Chile Universidad Los Andes, Chile