Short-course Antibiotics vs Standard Course Antibiotics in Patients With Cholangitis
Status:
Not yet recruiting
Trial end date:
2026-09-01
Target enrollment:
Participant gender:
Summary
The goal of this multicentre randomized controlled trial is to investigate if a very
short-course of antibiotics (1 day) for cholangitis after adequate drainage is non-inferior
with respect to clinical cure in comparison with a standard course of antibiotics (4 to 7
days). Secondary objectives include:
- Will a one-day course of antibiotics for cholangitis after adequate drainage be
non-inferior with respect to relapse of cholangitis and mortality in comparison with a
standard course of antibiotics?
- Will a one-day course of antibiotics for cholangitis after adequate drainage result in
less adverse drug events in comparison with a standard course of antibiotics?
- Will a one-day course of antibiotics for cholangitis after adequate drainage reduce
length of hospital stay?
- Will a one-day course of antibiotics for cholangitis after adequate drainage improve
quality of life?
- Will a one-day course of antibiotics for cholangitis after adequate drainage be
cost-effective?
Phase:
N/A
Details
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development