Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS)
Status:
Completed
Trial end date:
2008-02-01
Target enrollment:
Participant gender:
Summary
Serotonergic antidepressants are clearly effective for premenstrual syndrome (PMS). This
study compares short-term treatment (4 months) and long-term treatment (12 months) with
sertraline to determine how long medication should be continued after achieving a good
response, how soon symptoms return after stopping medication, and whether symptoms are
further improved with long-term treatment. Multiple hypotheses include the following: The
percent of relapsed subjects is greater with short-term treatment; relapse is swifter with
short-term treatment; relapsed subjects improve swiftly when returned to medication; patient
satisfactions and quality of life are more improved with long-term treatment.
Phase:
Phase 4
Details
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)