Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure

• Status: Active, not recruiting
• Trial end date: 2020-12-15
• Target enrollment: 0
• Participant gender: All

Summary

Autologous PRP currently has many uses in surgical and medical therapy. Compared with other regenerative therapies, PRP is easy-to-prepare, low-cost, and does not require complex equipment. The use of autologous PRP avoids immunological side effects. Data is lacking on the use of PRP in the treatment of anal fissure. This study evaluated PRP as an alternative medical treatment for chronic anal fissures.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: KTO Karatay University
• Collaborator: Istanbul Medipol University Hospital
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• between 18 and 65 years of age with painful defecation of at least 2 months duration and diagnosed with anal fissure between January and October 2019 were included.

• The diagnosis of chronic anal fissure required :

• the presence of internal sphincter muscle fibers in the base of the fissure

• hypertrophic anal papillae on digital rectal examination

Exclusion Criteria:

• Patients with physical examination findings that did not meet the definition of chronic anal fissure

• with painful defecation for less than 2 months,

• atypical fissure location or multiple anal fissures away from the midline

• inflammatory bowel disease

• cancer

• history of trauma

• tuberculosis

• immune suppression

• sexually transmitted disease

• a disease possibly associated with a fissure

• a history of anal surgery

• previous treatment for anal fissure

• current pregnancy .