Short Term, High Dose Vitamin D Supplementation for COVID-19
Status:
Completed
Trial end date:
2021-04-10
Target enrollment:
Participant gender:
Summary
Coronavirus-2019 (COVID-19) caused by severe acute respiratory syndrome-associated
coronavirus-2 (SARS-CoV-2) has affected the lives of millions of individuals globally and
severely strained the medical community. Pre-symptomatic and asymptomatic SARS-CoV-2 positive
individuals far outnumber the symptomatic ones or those with severe disease. The transmission
potential of SARS CoV-2 is potentially greator than earlier viral outbreaks of SARS-CoV and
MERS-CoV. Identification of asymptomatic carriers of SARS-CoV-2 infection is paramount to
contain viral infection because of high transmission potential Routine measures of social
distancing, personal hand hygiene and limited outdoor contact activities have shown benefits
to limit corona virus infection. However, the role of vitamin D in SARS-CoV-2 infection is
not explored despite the knowledge of an immunomodulatory role and protective effect of
vitamin D against viral infections. It has been found that mortality from COVID-19 is more in
countries with vitamin D deficiency.
The role of therapeutic vitamin D supplementation in asymptomatic individuals with vitamin-D
deficiency and COVID-19 is not known. Immune-modulatory effect of vitamin D is likely to be
observed at 25(OH)D levels which are considered higher than that required for normal bone
metabolism.An earlier SARS-CoV-2 negativity may have significant public health benefits in
limiting the spread of the disease. Therefore, we hypothesise that high dose vitamin D
supplementation in patients with COVID-19 and vitamin D deficiency may lead to SARS-CoV-2
negativity in greater proportions of patients associated with decrease in serological markers
of inflammation.
Phase:
N/A
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research