Short Course Terlipressin for Control of Acute Variceal Bleeding

• Status: Completed
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether 24 hours of Terlipressin is as effective as 72 hours of Terlipressin in preventing re-bleed once esophageal variceal bleed has been controlled with endoscopic therapy (variceal band ligation or sclerotherapy) in low to moderate risk variceal bleed patients and hence can save cost and may decrease length of hospital stay especially in the I.C.U or high dependency units.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aga Khan University
• Collaborator: Ferozsons Laboratories Ltd.
• Treatments: Lypressin; Terlipressin

Criteria

Inclusion Criteria:

• Acute esophageal variceal bleed

• Liver cirrhosis

• Child's score Exclusion Criteria:

• Patient on Mechanical ventilator and or ionotropic support

• Active angina, Recent Myocardial infarction or dynamic EKG changes

• Failure to control variceal bleed on initial endoscopy

• Gastric variceal bleed

• Spontaneous bacterial peritonitis at presentation

• Hepatocellular carcinoma or other liver metastatic malignancy

• Portal vein thrombosis