Short Course Radiotherapy Followed Intensive Chemotherapy With Delayed Surgery for Rectal Cancer With Synchronous Distant Metastasis

• Status: Recruiting
• Trial end date: 2022-12-01

Summary

Radical treatment of primary rectal cancer with synchronous distant metastases includes surgical resection of primary and metastatic lesion. However, primary rectal cancer in case of metastasized disease are often locally advanced disease and need downsizing before surgery. It is reported that pelvic recurrence rates and distant metastasis rates outside liver are 30~35% and 60%, respectively. Therefore, combined treatment with radiotherapy and chemotherapy is used. However, the sequence of treatment modalities is not yet definitely established and preoperative chemoradiotherapy and surgical resection is accepted as an option of treatment. Conventional long course chemoradiotherapy delays administration of full-dose chemotherapy, and metastatic lesion can be progressed during chemoradiotherapy. In present study, we evaluate the efficacy of short course radiotherapy (SCRT) followed by full-dose chemotherapy with delayed surgical resection of the primary tumor and metastases.

• Phase: Phase 2

Details

• Lead Sponsor: Korea Cancer Center Hospital
• Collaborators: Catholic University of Korea, Seoul St. Mary`s Hospital; Catholic University of Korea, Yeouido St. Mary`s Hospital; Catholic University of Korea, Yeouido St. Mary's Hospital; Chungnam National University Hospital; Dongtan Sacred Heart Hospital; Gachon University Gil Medical Center; Gangnam Severance Hospital; Kyung Hee University Hospital at Gangdong; Pusan National University Yangsan Hospital; Severance Hospital; The Catholic University of Korea; The Koreran Society of Coloproctology; Wonju Severance Christian Hospital
• Treatments: Bevacizumab; Cetuximab